abstract：:T-2 toxin is one of class A trichothecene mycotoxins produced by Fusarium, presenting genotoxic, cytotoxicity, and immunotoxicity for animals and humans. Therefore, It is urgent to establish a rapid test method with high sensitivity, good selectivity and reliability. In this research, by adjusting the synthesis condit...

authors： Zhao X,Wang Y,Li J,Huo B,Qin Y,Zhang J,Chen M,Peng Y,Bai J,Li S,Gao Z

更新日期：2021-10-05 00:00:00

abstract：:Arsenic (As), as well as its various compounds have been widely used for nearly 4000 years either as drugs or poisons. These compounds are valuable in the treatment of various diseases ranging from dermatosis to cancer, thereby emphasizing their important roles as therapeutic agents. The ability of As compounds, espec...

authors： Liu G,Song Y,Li C,Liu R,Chen Y,Yu L,Huang Q,Zhu D,Lu C,Yu X,Xiao C,Liu Y

更新日期：2021-10-05 00:00:00

abstract：:As primary industrial raw material, the widespread usage of bisphenol A (BPA) has resulted in sustained release and accumulation in the environment. Besides its endocrine-disrupting character, BPA was reported to generate excessive reactive oxygen species (ROS). However, the potential toxic mechanisms of the BPA-induc...

authors： Xiang D,Hou X

更新日期：2021-10-05 00:00:00

abstract：:The interactions between selected molecules (piperine, tacrine, curcumin and silibinin) and proteins (acetylcholinesterase and bovine serum albumin) were investigated by Fluorescence spectroscopy, molecular docking, molecular dynamics, free energy calculation and non-covalent interaction analysis. These binding charac...

authors： Saravanan K,Karthikeyan S,Sugarthi S,Stephen AD

更新日期：2021-10-05 00:00:00

abstract：:The title paper [Spectrochim. Acta A213 (2019): 391-396] reports an improvement of the "Poor Man's Kramers-Kronig analysis" and of the "Kramers-Kronig constrained variational analysis" thanks to an ad hoc modification of some analytical formulas existing in the literature. This ad hoc modification is not based on math...

authors： Rousseau E,Izard N,Bantignies JL,Felbacq D

更新日期：2021-10-05 00:00:00

abstract：:T cell immunotherapies have revolutionized treatment for a subset of cancers. Yet, a major hurdle has been the lack of facile and predicative preclinical animal models that permit dynamic visualization of T cell immune responses at single-cell resolution in vivo. Here, optically clear immunocompromised zebrafish were ...

authors： Yan C,Yang Q,Zhang S,Millar DG,Alpert EJ,Do D,Veloso A,Brunson DC,Drapkin BJ,Stanzione M,Scarfò I,Moore JC,Iyer S,Qin Q,Wei Y,McCarthy KM,Rawls JF,Dyson NJ,Cobbold M,Maus MV,Langenau DM

更新日期：2021-10-04 00:00:00

abstract：:Protein-rich droplets, such as stress granules, P-bodies, and the nucleolus, perform diverse and specialized cellular functions. Recent evidence has shown the droplets, which are also known as biomolecular condensates or membrane-less compartments, form by phase separation. Many droplets also contact membrane-bound or...

authors： Kusumaatmaja H,May AI,Knorr RL

更新日期：2021-10-04 00:00:00

abstract：:Symbiosis is a physiological phenomenon where organisms of different species develop social interdependencies through partnerships. Artificial agents need mechanisms to build their capacity to develop symbiotic relationships. In this paper, we discuss two pillars for these mechanisms: machine education (ME) and bi-dir...

authors： Abbass H,Petraki E,Hussein A,McCall F,Elsawah S

更新日期：2021-10-04 00:00:00

abstract：:The creation of digital replicas of individuals, based on their data, gives birth to what experts in medical field called the 'personal digital twin'. This new 'digital self' raises many difficulties, in sociology, in science and in law. This article presents the main issues from a legal point of view. Most of the str...

authors： Teller M

更新日期：2021-10-04 00:00:00

abstract：:Robust inflammatory responses are critical to survival following respiratory infection, with current attention focused on the clinical consequences of the Coronavirus pandemic. Epigenetic factors are increasingly recognized as important determinants of immune responses, and EZH2 is a prominent target due to the availa...

authors： Kitchen GB,Hopwood T,Gali Ramamoorthy T,Downton P,Begley N,Hussell T,Dockrell DH,Gibbs JE,Ray DW,Loudon ASI

更新日期：2021-10-01 00:00:00

abstract：:E74-like E26 transformation-specific (ETS) transcription factor 3 (ELF3), is a member of the ETS transcription factor family, and has been characterized as an epithelial cell-specific transcription factor. The role of ELF3 in tumor progression remains to be elucidated. Previous studies have indicated that loss of ELF3...

authors： Liu Y,Wang S,Zhou R,Li W,Zhang G

更新日期：2021-10-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most lethal cancer among female genital tumours. Standard therapies, including postoperative chemotherapy, exhibit high proportions of recurrence and resistance. Novel therapeutic strategies are combined with chemotherapy. Emerging studies have demonstrated that nigericin, an H+,...

authors： Zhou B,Wang C,Liu X,Wu B,Li J,Yao S,Zhang S

更新日期：2021-10-01 00:00:00

abstract：:Because the US population is living to an older age, the number of individuals with cognitive impairment and periodontitis is increasing, as both conditions/diseases increase with age. Dental informed consent best practices for dental/periodontal treatment of individuals with cognitive impairment have not been explore...

authors： Alsaleh A,Kapila A,Shahriar I,Kapila YL

更新日期：2021-10-01 00:00:00

abstract：Background:Transverse myelitis (TM) in childhood is a rare disorder characterized by the presence of spinal cord inflammation. Gait difficulty in children with TM is common; however, there is a paucity of literature regarding quantitative assessment of gait in children and adolescents with TM. Objectives:To characteri...

authors： Hwang M,Flanagan A,Graf A,Kruger KM,Scullion N,Tayne S,Altiok H

更新日期：2021-10-01 00:00:00

abstract：:The black soldier fly (BSF) Hermetia illucens has a strong tolerance to cadmium stress. This helps to use BSF in entomoremediation of heavy metal pollution. Rich metallothionein (MT) proteins were thought to be important for some insects to endure the toxicity of heavy metal. We identified and characterized three MTs ...

authors： Zhang J,Shi Z,Gao Z,Wen Y,Wang W,Liu W,Wang X,Zhu F

更新日期：2021-10-01 00:00:00

abstract：:The COVID-19 pandemic in the first months of 2020 posed an unprecedented threat to the health of the world's population. In this longitudinal design study, we elaborated the typology of 27 European countries based on the complete beginnings of the ongoing COVID-19 pandemic based on health indicators and contextual var...

authors： Dzúrová D,Květoň V

更新日期：2021-10-01 00:00:00

abstract：:Sulforaphane and sulforaphene are isothiocyanate compounds derived from cruciferous vegetables that have demonstrated antiproliferative properties against colon cancer. However, the underlying mechanism of action of these two compounds has yet to be elucidated. The aim of the present study was to examine the effects o...

authors： Gao L,Du F,Wang J,Zhao Y,Liu J,Cai D,Zhang X,Wang Y,Zhang S

更新日期：2021-10-01 00:00:00

abstract：:Neuromyelitis optica (NMO) is an autoimmune disease that primarily targets astrocytes. Autoantibodies (NMO-IgG) against the water channel protein, aquaporin 4 (AQP4), are a serologic marker in NMO patients, and they are known to be responsible for the pathophysiology of the disease. In the brain, AQP4 is mainly expres...

authors： Cho S,Lee H,Jung M,Hong K,Woo SH,Lee YS,Kim BJ,Jeon MY,Seo J,Mun JY

更新日期：2021-10-01 00:00:00

abstract：:Periodontitis is a multi-etiologic infection characterized clinically by pathologic loss of the periodontal ligament and alveolar bone. Herpesviruses and specific bacterial species are major periodontal pathogens that cooperate synergistically in producing severe periodontitis. Cellular immunity against herpesviruses ...

authors： Naqvi AR,Slots J

更新日期：2021-10-01 00:00:00

abstract：:Solid fuel is a the most dominant energy source for household usages in developing countries. In this study, emission characteristics on organic carbon (OC), elemental carbon (EC) and fifty-two polycyclic aromatic hydrocarbons (PAHs) in gaseous and particulate phases from seven fuel-stove combinations were studied in ...

authors： Zhang B,Sun J,Jiang N,Zeng Y,Zhang Y,He K,Xu H,Liu S,Hang Ho SS,Qu L,Cao J,Shen Z

更新日期：2021-10-01 00:00:00

abstract：:It is estimated that 5% of the global cancer burden, or approximately 690,000 cancer cases annually, is attributable to human papillomavirus (HPV). Primary prevention through prophylactic vaccination is the best option for reducing the burden of HPV-related cancers. Most high-income countries (HICs) have introduced th...

authors： Dahlstrom KR,Day AT,Sturgis EM

更新日期：2021-10-01 00:00:00

abstract：:RNA interference has been proved as an efficient technology for pest control through the silencing of essential genes of targeted insects. We had previously shown that the expression of double-stranded RNAs (dsRNAs) in plastids of plants offers a great potential for efficiently controlling Colorado potato beetle (CPB,...

authors： Ren B,Cao J,He Y,Yang S,Zhang J

更新日期：2021-10-01 00:00:00

abstract：:Multiple sulfur (δ34Ssulfate, Δ33Ssulfate, & Δ36Ssulfate), nitrogen and oxygen (δ15Nnitrate & δ18Onitrate) and strontium (87Sr/86Sr) isotope compositions of precipitation collected from Seoul, South Korea were analyzed to study the sources, transportation and deposition of air pollutants in East Asia. The δ34Ssulfate ...

authors： Kim Y,Lee I,Farquhar J,Kang J,Villa IM,Kim H

更新日期：2021-10-01 00:00:00

abstract：:The aim of the present study was to compare the immunohistochemical expression of glucose transporter 1 (GLUT1) between the most common histological types of renal cell carcinoma (RCC), and to determine whether a correlation between GLUT1 expression and nuclear grade or tumor size exists. A total of 19 RCC samples wer...

authors： Ogorevc M,Strikic A,Tomas SZ

更新日期：2021-10-01 00:00:00

abstract：:Patients with gastric cancer (GC) have a poor prognosis, which is mainly due to the low rate of early diagnosis. The present study aimed to evaluate whether circulating microRNA-130b (miR-130b) and blood routine parameters [neutrophil count (N#), lymphocyte count (L#), monocyte count (M#), neutrophil percentage (N%), ...

authors： Chen J,Liu Z,Gao G,Mo Y,Zhou H,Huang W,Wu L,He X,Ding J,Luo C,Long H,Feng J,Sun Y,Guan X

更新日期：2021-10-01 00:00:00

abstract：SUMMARY:At Texas Health Resources, the well-being of our patients, our workforce, and our communities has long been at the core of who we are and the driving force behind business decisions, employee interactions, programs, practices, and the patient care we deliver. It is in our DNA, from our vision "to partner with y...

authors： Berdan BE

更新日期：2021-10-01 00:00:00

abstract：:Vascular calcification is a major risk factor for cardiovascular disease and accounts for a large proportion of deaths from cardiovascular disease in patients with chronic kidney disease. The high incidence, rapid progression and irreversibility of vascular smooth muscle cell (VSMC) calcification in patients has attra...

authors： Zhang Y,Tang N,Zhou J

更新日期：2021-10-01 00:00:00

abstract：:Since 2009, a community-based, collaborative exemplar in Richmond, Virginia, involving 8 satellite clinics of the state health department, has been implemented within public housing units to focus on prevention and access to care. These satellite centers, known a resource center (RCs), are staffed by public health nur...

authors： Cooper J,Bejster M,Policicchio J,Langhorne T,Jackson S,Shelton P,Toney S

更新日期：2021-10-01 00:00:00

abstract：:In situations where an excessive generation of reactive oxygen species overwhelms antioxidant capacity, a harmful effect on sperm function is exerted. Antioxidants are molecules capable of minimizing this detrimental effect, which is important in pig sperm due to the high content of polyunsaturated fatty acids in thei...

authors： Ribas-Maynou J,Mateo-Otero Y,Delgado-Bermúdez A,Bucci D,Tamanini C,Yeste M,Barranco I

更新日期：2021-10-01 00:00:00

abstract：:The present study aimed to establish a mouse model of patient-derived castration-resistant prostate cancer (CRPC) xenograft tumors, and to evaluate the effects of various doses of metformin on phospholipase Cε (PLCε) expression and the neurogenic locus notch homolog protein 1 (Notch1)/hairy and enhancer of split 1 and...

authors： Li Q,Xu K,Tian J,Lu Z,Pu J

更新日期：2021-10-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common types of malignancy worldwide and is accompanied by both high mortality and morbidity rates. Homeobox B13 (HOXB13) has been reported to act as a tumor suppressor gene in multiple types of human cancer. The present study aimed to investigate the effects and potential underl...

authors： Geng H,Liu G,Hu J,Li J,Wang D,Zou S,Xu X

更新日期：2021-10-01 00:00:00

abstract：:Our study aimed to describe levothyroxine prescription patterns and trends over time among pregnant women with subclinical hypothyroidism (SCH) in the United Kingdom. We used data from the Clinical Practice Research Datalink linked to its Pregnancy Register and the Hospital Episode Statistics database from 1998 to 201...

authors： Yu YH,Filion KB,Reynier P,Platt RW,Yu OHY,Grandi SM

更新日期：2021-10-01 00:00:00

abstract：...

authors： Liu R,Meng J,Lou D

更新日期：2021-10-01 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic disease. SGL5213, which is minimally absorbed and is restricted to the intestinal tract, is a potent intestinal sodium-glucose cotransporter 1 (SGLT1) inhibitor. In this study, we investigated the protective effect of SGL5213 in a rodent mod...

authors： Honda Y,Ozaki A,Iwaki M,Kobayashi T,Nogami A,Kessoku T,Ogawa Y,Tomeno W,Imajo K,Yoneda M,Saito S,Nagashima Y,Nakajima A

更新日期：2021-10-01 00:00:00

abstract：:Osteoporosis is a severe bone disease commonly occurring in older males and postmenopausal females. Previous studies have shown that long non‑coding (lnc)RNA growth arrest‑specific 5 (GAS5) serves an important role in osteoporosis. However, its role is unclear and requires further exploration. The relative expression ...

authors： Wu W,Li Q,Liu YF,Li Y

更新日期：2021-10-01 00:00:00

abstract：:Heme oxygenase‑1 (HO‑1) has been reported to be upregulated following renal ischemia‑reperfusion injury (IRI) and plays a key cytoprotective role; however, the underlying molecular mechanisms of its protective effects remain poorly understood. In the present study, in order to further elucidate the molecular mechanism...

authors： He Y,Li H,Yao J,Zhong H,Kuang Y,Li X,Bian W

更新日期：2021-10-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) refers to hemorrhage caused by spontaneous rupture of blood vessels in the brain. Brain injury due to ICH leads to catastrophic effects resulting from the formation of hematoma and oxidative stress caused by components of lysed erythrocytes. However, not all neurons in the area surroundi...

authors： Wang J,Chen Y,Liang J,Cao M,Shen J,Ke K

更新日期：2021-10-01 00:00:00

abstract：:Toxicological studies of O-ethyl-O-(4-nitrophenyl) phenylphosphonothioate (EPN) to aquatic vertebrates have been reported, but no reports on toxic mechanism was reported. As zebrafish (Danio rerio) embryos were exposed to EPN, no changes in their survival and hatching rates were observed until 96 h post fertilization ...

authors： Choe H,Kim MJ,Jeon HJ,Kim K,Kim C,Park J,Shin J,Lee SR,Lee SE

更新日期：2021-10-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a cancer associated with high mortality (accounting for 3.1/100,000 deaths per year in Brazil in 2013) and a high frequency of amplification in the expression of the epidermal growth factor receptor (EGFR). Treatment with the EGFR inhibitor cetuximab leads to drug resistance in p...

authors： Yin P,Cui S,Liao X,Yao X

更新日期：2021-10-01 00:00:00

abstract：:Modificated lignins can affect enzymatic hydrolysis efficiency (EHE) because of changing physicochemical properties of lignin. In this study, carboxylated and quaternized lignin (CQL) and hydroxymethylated lignin (HML) were prepared to explore the effect of lignin modification on cellulase adsorption and EHE of p-tolu...

authors： Xiong Q,Qiao J,Wang M,Li S,Li X

更新日期：2021-10-01 00:00:00